(Bloomberg) — Asian stocks are poised to end their longest winning run since 1988 as restrictions to curb the pandemic overshadowed progress toward a vaccine. Treasuries gained.Stocks had modest declines across most of the region. S&P 500 futures fluctuated with the benchmark closing at its session low after New York City shut schools because of rising infections. Tokyo raised its coronavirus alert to the highest of four levels Thursday. Pfizer Inc. advanced earlier after saying its vaccine was 95% effective, paving the way to apply for the first U.S. regulatory authorization for a coronavirus shot within days.The Bloomberg Dollar Spot Index was near its lowest since April 2018. An MSCI gauge of Asian stocks had risen for 13 consecutive sessions to Wednesday.Investors are reining in some of the euphoria that propelled global stocks to record highs and saw a rotation into value shares in the past week on positive news about vaccine developments. Instead, money managers remained focused on the latest coronavirus data showing disturbingly high infection rates in Europe and the U.S., where deaths from the coronavirus surpassed 250,000. Tokyo’s higher alert comes as the city was set on Thursday to record more than 500 new cases for the first time, according to broadcaster TV Asahi. “We are expecting tough times in coming months because of the resurgence of cases, but in terms of the longer term recovery path, the vaccine was a very important news milestone,” Melda Mergen, Columbia Threadneedle Investments deputy global head of equities, said on Bloomberg TV. “We think that the cyclical recovery is going to come back but there are going to be some bumps along the road.”Elsewhere, Bitcoin was back below $18,000 after surging above that level as cryptocurrencies roared back to life. Oil fell and gold was steady.Here are some events to watch out for this week:Brexit talks look set to continue as the U.K. and EU approach the latest deadline.Bloomberg New Economy Forum virtually convenes global leaders to discuss trade, growing political populism, climate change, and the pandemic. Through Nov. 19.Bank Indonesia rate decision Thursday.These are the main moves in markets:StocksS&P 500 futures were little changed as of 1:23 p.m. in Tokyo. The S&P 500 Index fell 1.2%.Topix index fell 0.3%.The MSCI Asia Pacific Index fell 0.3%.Australia’s S&P/ASX 200 Index was little changed.Kospi index fell 0.5%.Hang Seng Index fell 0.6%.Shanghai Composite Index rose 0.1%.Euro Stoxx 50 futures declined 0.9%.CurrenciesThe yen was at 103.81 per dollar, up 0.1%.The offshore yuan traded at 6.5654 per dollar.Bloomberg Dollar Spot Index rose 0.1%.The euro was at $1.1846.The British pound fell 0.3% to $1.3231.BondsThe yield on 10-year Treasuries fell two basis points to 0.85%.Australia’s 10-year bond yield was at 0.89%.CommoditiesWest Texas Intermediate crude fell 0.8% to $41.48 a barrel.Gold dipped 0.3% to $1,867.46 an ounce.For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.©2020 Bloomberg L.P.